Intramural Research

What this funds

The NINDS IRP conducts research and research training on the NIH campus. The IRP spans basic, translational, and clinical research in neuroscience, neurology, and neurosurgery and hosts core facilities providing state-of-the-art research technologies. The program also benefits from the NIH Clinical Center and partners with local hospitals and extramural scientists. Research Identifying biomarkers in ALS: Recent advances demonstrate the value of the collaborative and multidisciplinary approach to research facilitated by the IRP. For example, using advanced machine-learning methods, a new study identified a set of 33 blood-based proteins that can distinguish individuals with ALS from healthy-bodied people with very high accuracy.11 Importantly, the same biomarker profile was detectable in people before they developed symptoms, suggesting that ALS-related biological changes begin years earlier than clinical Improving the understanding of dementia: An IRP study estimated that an individual age 55 in the United States today has a 42 percent lifetime risk of developing dementia by age 95, projecting the annual number of new dementia cases will nearly double by 2060.12 IRP research is also uncovering the biological underpinnings of dementia. Researchers found a mechanism in which a specialized population of immune cells (CD8+ T cells) helps slow the spread of toxic tau protein in neurodegenerative diseases.13 When these T cells are removed or blocked, tau pathology accelerates, suggesting this immune response could be leveraged to slow diseases like Alzheimer's and Chronic Traumatic Encephalopathy (repeated impacts to the head). Budget Policy: The FY 2027 President's Budget request for the Intramural Research Program is and monitoring of extramural research grants, training awards, and research contracts (including program evaluation, budget and policy analysis, regulatory compliance, and enhanced patient and community engagement activities. RMS also supports internal initiatives that promote a positive workplace and a commitment toward zero harassment. Budget Policy: The FY 2027 President's Budget request for Research Management and Support National Institute of Neurological Disorders and Stroke 1 The FY 2026 President's Budget proposed consolidating the 27 NIH Institutes and Centers into an 8- Institute structure, while maintaining the Office of the Director and the Building and Facilities account. 2 The FY 2025 House bill proposed consolidating the 27 NIH Institutes and Centers into a 12-Institute structure, while maintaining the Office of the Director and the Building and Facilities account. 3 Includes funds derived by transfer from the NIH Innovation Account under the 21st Century Cures National Institute of Neurological Disorders and Stroke Detail of Full-Time Equivalent Employment (FTE)

Extracted from NIH - National Institute of Neurological Disorders and Stroke, p. 11. Verbatim; nothing here is paraphrased.

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