# Project EMR-04 — BASIC OPERATIONAL MEDICAL SCIENCE

**Program element:** 0601122E — Emerging Opportunities  
**Project:** EMR-04  
**Component:** Defense-Wide  
**Appropriation:** 0400 — RDT&E, Defense-Wide  
**Budget Activity:** 1 — Basic Research  
**Vintage:** President's Budget PB2027  
**Canonical URL:** https://hitchintel.com/programs/0601122E/EMR-04  
**Parent:** https://hitchintel.com/programs/0601122E

## Summary

Project EMR-04 — BASIC OPERATIONAL MEDICAL SCIENCE requests $96.6M in FY2027, 25% of the $387.6M requested for program element 0601122E, up 24% on FY2026. 9 R-2A activities decompose the request.

## Funding profile

| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 0.0 |
| FY2026 | Enacted | 77.9 |
| FY2027 | Request | 96.6 |
| FY2028 | Outyear | 131.0 |
| FY2029 | Outyear | 133.1 |
| FY2030 | Outyear | 138.5 |
| FY2031 | Outyear | 140.5 |

> Estimate types are not summed. This project is one leaf of PE 0601122E; the PE total is the sum of its projects, never added to them.

## What project EMR-04 buys

The Basic Operational Medical Science project will explore and develop basic research in medical-related information and technology leading to fundamental discoveries, tools, and applications critical to overcoming DoW challenges. This project will address the Department's identified warfighter medical care needs related to prevention and treatment of infectious disease, real-time healthcare interventions of acute and chronic illness and injury, and interventions for improved warfighter resilience and performance against operational stressors. Prior to FY 2026, efforts in this PE were funded in PE 0601117E, Project MED-01.

## Activities (R-2A) — 9

| Activity | FY2025 | FY2026 | FY2027 | Move | Page |
|---|---|---|---|---|---|
| Basic Operational Medical Science Studies and Concepts | — | 6.5 | 50.9 | +685% | [a4](https://hitchintel.com/programs/0601122E/EMR-04/a4) |
| Network of Optimal Dynamic Energy Signatures (NODES) | — | 11.5 | 14.4 | +25% | [a3](https://hitchintel.com/programs/0601122E/EMR-04/a3) |
| CoasterChase | — | 13.0 | 12.1 | −7% | [a2](https://hitchintel.com/programs/0601122E/EMR-04/a2) |
| Anesthetics for Battlefield Care (ABC) | — | 10.5 | 10.3 | −2% | [a0](https://hitchintel.com/programs/0601122E/EMR-04/a0) |
| Synthetic Hemo-technologies to Locate & Disinfect (SHIELD) | — | 8.7 | 8.9 | +2% | — |
| Simulating Microbial Systems (SMS) | — | 18.1 | — | −100% | — |
| Objective Prediction of Team Effectiveness via Models of Performance Outcomes (OP TEMPO) | — | 4.2 | — | −100% | — |
| Combatting Anti-Microbial Resistant Pathogens | — | 3.9 | — | −100% | — |
| Physiological Overmatch | — | 1.5 | — | −100% | — |

> Activities carry the prior, current and budget year only — no five-year plan. In the request year they partition this project exactly; in earlier years they can under-cover it.

### Basic Operational Medical Science Studies and Concepts

- Initiate exploration of approaches to improve assessments and diagnostics for predictive and preventative purposes. - Identify assessment paradigm for biological and artificial intelligence problem solving separately and in tandem. - Investigate high-throughput characterization technologies to examine molecular interactions and…

Full year-by-year narrative: https://hitchintel.com/programs/0601122E/EMR-04/a4

### Network of Optimal Dynamic Energy Signatures (NODES)

- Generalize computational models by incorporating available data from public protein databases. - Incorporate machine learning methods with physics-based models to provide speed and accuracy of function prediction. - Evaluate the optimized model performance in capability demonstrations to predict molecular function from folding, binding…

Full year-by-year narrative: https://hitchintel.com/programs/0601122E/EMR-04/a3

### CoasterChase

- Integrate and miniaturize neuromodulation and sensing technologies within a single ingestible form factor for closed-loop control. - Further develop, test, and finalize biomarker sensing for identified biomarker(s). - Finalize integration of stimulation modalities (electrical and/or mechanical) to modulate the systemic stress response.

Full year-by-year narrative: https://hitchintel.com/programs/0601122E/EMR-04/a2

### Anesthetics for Battlefield Care (ABC)

- Begin to define neural circuits involved in safe anesthesia effects. - Demonstrate novel actionable molecular targets that contribute to the effects of anesthesia. - Complete computational screens and select hit drug candidates against novel molecular targets. - Initiate novel drug design for molecular targets of anesthesia.

Full year-by-year narrative: https://hitchintel.com/programs/0601122E/EMR-04/a0

### Synthetic Hemo-technologies to Locate & Disinfect (SHIELD)

**FY2027 planned work.** - Demonstrate that developed countermeasures prevent pathogen growth and increase host survival in single fungal and bacterial pathogen exposures in blood following burn trauma. - Demonstrate that countermeasures are non-toxic and do not produce a response from the immune system in the host following burn trauma. - Validate the countermeasures' ability to prevent pathogen growth and increase host survival in single fungal and single bacterial pathogen exposures following burn trauma. - Refine development of countermeasures that prevent pathogen growth and increase host survival in mixed-pathogen (fungal and bacterial) exposures in blood following blast trauma.

**FY2026 to FY2027 change.** The FY 2027 increase reflects minor program repricing.

**FY2026 plans — current year.** - Produce countermeasures at scale to support animal model testing. - Complete validation of countermeasures' ability to prevent pathogen growth and increase host survival in single fungal and single bacterial pathogen exposures. - Refine development of countermeasures that prevent pathogen growth and increase host survival in single fungal and bacterial pathogen exposures in blood following burn trauma. - Refine development of countermeasures that are non-toxic and non-immunogenic to the host following burn trauma.

### Simulating Microbial Systems (SMS)

**FY2026 to FY2027 change.** The FY 2027 decrease reflects program completion.

**FY2026 plans — current year.** - Begin pressure tests to experimentally validate simulations for tailored DoW use cases. - Investigate and evaluate new approaches and combinations thereof to develop simulations of fundamental biological processes and responses to stimuli or stress. - Begin validating simulations of fundamental biological processes and responses to stimuli or stress. - Develop approaches to evaluate computational parameter space to optimize simulations of fundamental biological processes.

### Objective Prediction of Team Effectiveness via Models of Performance Outcomes (OP TEMPO)

**FY2026 to FY2027 change.** The FY 2027 decrease reflects program completion.

**FY2026 plans — current year.** - Complete data collection of biobehavioral signatures of warfighter and team performance. - Validate bio-behavioral signatures using predictive models of team performance. - Conduct Critical Task Analysis for two additional teaming-related use cases and develop custom metrics for each use case. - Create testbeds for two additional teaming-related use cases to explore generalizability of bio-behavioral signatures and predictive models.

### Combatting Anti-Microbial Resistant Pathogens

**FY2026 to FY2027 change.** The FY 2027 decrease reflects program completion.

**FY2026 plans — current year.** - Demonstrate medical countermeasures against pathogenic bacteria and/or their toxins with greater efficacy than state-of-the-art antibiotic therapies.

### Physiological Overmatch

**FY2026 to FY2027 change.** The FY 2027 decrease reflects program completion.

**FY2026 plans — current year.** - Identify molecules in the blood that correspond to sleep loss and its effects on cognitive function. - Identify potential intervention targets for mitigating deleterious effects of sleep loss.

## What is NOT on this page

Congressional marks, the R-2 mission description and acquisition strategy, the industry vs government split of the whole request, and related program elements are recorded at **program-element** grain — an NDAA mark lands on a PE, never on a project. They are at https://hitchintel.com/programs/0601122E.

## Source & machine access

- **Source:** FY2027 Office of the Secretary of Defense RDT&E Budget Justification, Exhibits R-2/R-2A/R-3, PE 0601122E project EMR-04 (PB PB2027).
- **MCP:** `mcp.hitchintel.com` — `budget_get_program_element(pe="0601122E")`.

*HitchAI is an independent intelligence service, not affiliated with the U.S. Department of Defense. Budget figures are requests/estimates, not obligations.*