# Anesthetics for Battlefield Care (ABC)

**R-2A activity** of project EMR-04 — BASIC OPERATIONAL MEDICAL SCIENCE  
**Program element:** 0601122E — Emerging Opportunities  
**Component:** Defense-Wide · **Budget Activity:** 1  
**Vintage:** President's Budget PB2027  
**Canonical URL:** https://hitchintel.com/programs/0601122E/EMR-04/a0  
**Parent:** https://hitchintel.com/programs/0601122E/EMR-04

## Summary

This activity requests $10.3M in FY2027, 11% of project EMR-04, down 2.1% on FY2026. The R-2A exhibit describes it across FY2026–FY2027, including what the FY2027 money is planned to buy.

## What the FY2027 request buys

**FY2027 planned work.** - Begin to define neural circuits involved in safe anesthesia effects. - Demonstrate novel actionable molecular targets that contribute to the effects of anesthesia. - Complete computational screens and select hit drug candidates against novel molecular targets. - Initiate novel drug design for molecular targets of anesthesia.

**FY2026 to FY2027 change.** The FY 2027 decrease reflects minor program repricing.

## Before the request year

**FY2026 plans — current year.** - Identify novel molecular targets of anesthesia. - Conduct computational modeling to test efficacy of small molecules binding to established protein targets. - Define neural circuitry mechanisms that underlie anesthetic actions in an animal model. - Experimentally validate anesthesia associated pathways and molecular targets identified in screening approaches. - Validate and demonstrate predictive capabilities of physiological computational model of anesthetic drugs in single/poly-trauma physiologies.

## Funding

| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2026 | Enacted | 10.5 |
| FY2027 | Request | 10.3 |

> Prior, current and budget year only — an R-2A activity carries no five-year plan. It sums exactly into its project in the request year and not necessarily in any other.

## Other activities in project EMR-04

- [Basic Operational Medical Science Studies and Concepts](https://hitchintel.com/programs/0601122E/EMR-04/a4) — FY2027 50.9
- [Network of Optimal Dynamic Energy Signatures (NODES)](https://hitchintel.com/programs/0601122E/EMR-04/a3) — FY2027 14.4
- [CoasterChase](https://hitchintel.com/programs/0601122E/EMR-04/a2) — FY2027 12.1
- Synthetic Hemo-technologies to Locate & Disinfect (SHIELD) — FY2027 8.9
- Simulating Microbial Systems (SMS) — FY2027 —
- Objective Prediction of Team Effectiveness via Models of Performance Outcomes (OP TEMPO) — FY2027 —
- Combatting Anti-Microbial Resistant Pathogens — FY2027 —
- Physiological Overmatch — FY2027 —

## Source & machine access

- **Source:** FY2027 Office of the Secretary of Defense RDT&E Budget Justification, Exhibit R-2A, PE 0601122E project EMR-04 (PB PB2027). Narrative is the government's own text.
- **No marks, no contractors at this grain** — congressional marks land on the program element and R-3 performers on the project.
- **MCP:** `mcp.hitchintel.com` — `budget_get_activity`.

*HitchAI is an independent intelligence service, not affiliated with the U.S. Department of Defense. Budget figures are requests/estimates, not obligations.*