# Project LF1 — Life Sciences (Basic Research)

**Program element:** 0601384BP — Chemical and Biological Defense Program  
**Project:** LF1  
**Component:** Defense-Wide  
**Appropriation:** 0400 — RDT&E, Defense-Wide  
**Budget Activity:** 1 — Basic Research  
**Vintage:** President's Budget PB2027  
**Canonical URL:** https://hitchintel.com/programs/0601384BP/LF1  
**Parent:** https://hitchintel.com/programs/0601384BP

## Summary

Project LF1 — Life Sciences (Basic Research) requests $16.1M in FY2027, 59% of the $27.4M requested for program element 0601384BP, down 8.7% on FY2026. 1 R-2A activity decomposes the request.

## Funding profile

| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 20.4 |
| FY2026 | Enacted | 17.7 |
| FY2027 | Request | 16.1 |
| FY2028 | Outyear | 14.8 |
| FY2029 | Outyear | 14.0 |
| FY2030 | Outyear | 13.8 |
| FY2031 | Outyear | 13.7 |

> Estimate types are not summed. This project is one leaf of PE 0601384BP; the PE total is the sum of its projects, never added to them.

## What project LF1 buys

This Project (LF1) focuses on fundamental efforts to understand living systems' responses to biological or chemical agents to support detection, protection, diagnostics, and medical treatment. Research focuses on studying factors that influence the behavior of chemicals, toxins, and pathogens in relation to the host or target. Understanding host/agent interactions can drive the exploration of novel approaches to detect, diagnose or protect against threats. Research also focuses on medical countermeasures for improved efficacy against a wide array of current and future threat agents. This project is a key enabler supporting the Understand, Protect, and Mitigate portfolios.

## Activities (R-2A) — 1

| Activity | FY2025 | FY2026 | FY2027 | Move | Page |
|---|---|---|---|---|---|
| 1) Life Sciences | 20.4 | 17.7 | 16.1 | −9% | [a0](https://hitchintel.com/programs/0601384BP/LF1/a0) |

> Activities carry the prior, current and budget year only — no five-year plan. In the request year they partition this project exactly; in earlier years they can under-cover it.

### 1) Life Sciences

- Organoid Technology – Continue investigating cellular toxicity and metabolic profiles in organoids and evaluate relevance to safety/efficacy model data. Determine inflammatory signaling in models that are relevant to human cells. Evaluate and develop alternative models that mimic human response for rapid drug development, which can…

Full year-by-year narrative: https://hitchintel.com/programs/0601384BP/LF1/a0

## What is NOT on this page

Congressional marks, the R-2 mission description and acquisition strategy, the industry vs government split of the whole request, and related program elements are recorded at **program-element** grain — an NDAA mark lands on a PE, never on a project. They are at https://hitchintel.com/programs/0601384BP.

## Source & machine access

- **Source:** FY2027 Office of the Secretary of Defense RDT&E Budget Justification, Exhibits R-2/R-2A/R-3, PE 0601384BP project LF1 (PB PB2027).
- **MCP:** `mcp.hitchintel.com` — `budget_get_program_element(pe="0601384BP")`.

*HitchAI is an independent intelligence service, not affiliated with the U.S. Department of Defense. Budget figures are requests/estimates, not obligations.*