# Chemical and Biological Defense Program — Program Element 0602384BP

**Program element:** 0602384BP  
**Component:** Defense-Wide  
**Appropriation:** 0400 — RDT&E, Defense-Wide  
**Budget Activity:** 2 — Applied Research  
**Vintage:** President's Budget PB2027  
**Canonical URL:** https://hitchintel.com/programs/0602384BP

## Summary

Defense-Wide requests $207.2M in FY2027. In the FY2027 defense authorization, the House cut 4.8% (to $197.2M); the Senate funded it in full; House appropriators funded it in full.

## Funding profile

| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 223.8 |
| FY2026 | Enacted | 204.1 |
| FY2027 | Request | 207.2 |
| FY2028 | Outyear | 183.1 |
| FY2029 | Outyear | 173.7 |
| FY2030 | Outyear | 171.7 |
| FY2031 | Outyear | 169.1 |

> Estimate types are not summed — the profile mixes actuals, enacted law, the request, and outyear projections.

## Congressional marks (FY2027)

| Stage | Marked ($M) | Change ($M) |
|---|---|---|
| Request | 207.2 | — |
| House NDAA (HASC) | 197.2 | −10.0 |
| Senate NDAA (SASC) | 207.2 | +0.0 |
| House Approps (HAC-D) | 207.2 | +0.0 |

> FY2027 NDAA authorization marks, as of 2026-07-27. Not appropriations or final law.

## Projects (4)

| Project | Title | FY2025 actual | FY2026 enacted | FY2027 request | Move |
|---|---|---|---|---|---|
| UN2 | Understand (Applied Research) | 93.3 | 88.6 | 93.7 | +6% |
| PT2 | Protect (Applied Research) | 45.8 | 51.8 | 78.0 | +51% |
| MT2 | Mitigate (Applied Research) | 62.3 | 45.1 | 34.0 | −25% |
| EN2 | Enabling Investments (Applied Research) | 22.4 | 18.5 | 1.5 | −92% |

> Projects are the summable leaves: the program element total is their sum, never added to it.

### Project UN2 — Understand (Applied Research)

The Understand Applied Research Project provides the Joint Force with the abilities to detect, identify, and characterize chemical and biological (CB) threat agents. This includes classification and/or identification of the threat and potentially the amount of CB hazards in all physical states. Efforts provide the ability to characterize the CB hazard to a commander and develop a clear understanding of the current and predicted CB situation; collect, query, and assimilate information from sensors, intelligence and medical communities, etc., in near real time to inform decisions; and provide actual and potential impacts of CB hazards. Thrust Areas included in this Project are: (1) Chemical, Biological, Radiological, and Nuclear (CBRN) Battlespace Sensing, Alerting & Response (2) CBRN Decision Aids (3) CBRN Situational Awareness (4) Operational Diagnostics (5) Diagnostic Building Blocks (6) Emerging Threats (7) Diagnostic Building Blocks - Enhanced Biological Defense (8) Emerging Threats - Enhanced Biological Defense (9) Employment Characterization (10) Environmental Response (11) First Look (12) Host Response (13) Operational Biological Sensing (14) Emerging and Enhanced Biothreat Sensing (15) Unconventional Detection Modalities - Biological Detection (16) Operational Chemical Sensing - Chemical Detection (17) Modernized and Enhanced Chemical Sensing - Chemical Detection (18) Unconventional Detection Modalities - Chemical Detection (19) Technical Surprise (20) Technical Surprise - Enhanced Biological Defense (21) Technical Surprise - Threat Agent Science Data and Optimization (TASDO)

| Activity (R-2A) | FY2025 | FY2026 | FY2027 |
|---|---|---|---|
| 1) Chemical Biological Radiological Nuclear Battlespace Sensing, Alerting, and Response | 5.9 | 3.8 | 1.4 |
| 2) Chemical Biological Radiological Nuclear Decision Aids | 3.5 | 2.1 | 1.8 |
| 3) Chemical Biological Radiological Nuclear Situational Awareness | 18.5 | 14.6 | 8.6 |
| 4) Operational Diagnostics | 0.5 | 0.5 | 1.6 |
| 5) Diagnostic Building Blocks | 1.8 | 2.4 | 4.0 |
| 6) Emerging Threats | 1.1 | 1.5 | 2.4 |
| 7) Diagnostic Building Blocks - Enhanced Biological Defense | 2.3 | 0.8 | — |
| 8) Emerging Threats - Enhanced Biological Defense | 3.0 | 1.0 | — |
| 9) Employment Characterization | 4.8 | 4.6 | 6.3 |
| 10) Environmental Response | 4.8 | 5.6 | 6.1 |
| 11) First Look | 9.3 | 8.8 | 9.9 |
| 12) Host Response | 10.0 | 12.8 | 18.2 |
| 13) Operational Biological Sensing | 2.5 | 2.9 | 4.7 |
| 14) Emerging and Enhanced Biothreat Sensing | 6.2 | 9.0 | 2.0 |
| 15) Unconventional Detection Modalities - Biological Detection | 2.6 | 2.4 | 7.4 |
| 16) Operational Chemical Sensing - Chemical Detection | 5.0 | 2.6 | 1.9 |
| 17) Modernized and Enhanced Chemical Sensing - Chemical Detection | 3.3 | 3.4 | 1.8 |
| 18) Unconventional Detection Modalities - Chemical Detection | 2.2 | 2.3 | 2.0 |
| 19) Technical Surprise | 3.3 | 2.6 | 4.5 |
| 20) Technical Surprise - Enhanced Biological Defense | 2.8 | 3.0 | 3.0 |
| 21) Technical Surprise - Threat Agent Science Data and Optimization (TASDO) | — | 2.2 | 6.0 |

> R-2A activities carry the prior, current and budget year only — no five-year plan. Coverage is partial, so count them, never total them.

### Project PT2 — Protect (Applied Research)

The Protect Applied Research Project provides the Joint Force the ability to prevent the effects from exposure to chemical and biological hazards. PT2 emphasizes increasing protection capability and reducing physiological effects, preventing or reducing individual and collective exposures, applying prophylaxis to prevent or mitigate negative physiological effects, and protecting critical equipment in chemical and biological (CB) environments. Thrust Areas included in this Project are: (1) Biological Warfare Defense Prophylaxis (2) Biological Warfare Defense Prophylaxis - Enhanced Biological Defense (3) Air Purification Enhancements (4) All-Hazards & Respiratory Protection (5) Multifunctional Materials for Protection (MMfP) (6) Protective Garments (7) Enabling Science (8) Nerve Agent Prophylaxis

| Activity (R-2A) | FY2025 | FY2026 | FY2027 |
|---|---|---|---|
| 1) Biological Warfare Defense Prophylaxis | 13.4 | 16.4 | 20.9 |
| 2) Biological Warfare Defense Prophylaxis - Enhanced Biological Defense | 19.8 | 21.0 | 20.9 |
| 3) Air Purification Enhancements | 1.1 | 1.4 | 1.4 |
| 4) All-Hazards and Respiratory Protection | 0.7 | 1.5 | 1.9 |
| 5) Multifunctional Materials for Protection | 3.7 | 4.0 | 8.5 |
| 6) Protective Garments | 2.6 | 3.7 | 3.3 |
| 7) Enabling Science | 0.8 | 0.6 | — |
| 8) Nerve Agent Prophylaxis | 3.8 | 3.3 | 21.1 |

> R-2A activities carry the prior, current and budget year only — no five-year plan. Coverage is partial, so count them, never total them.

### Project MT2 — Mitigate (Applied Research)

The Mitigate Applied Research Project emphasizes the ability to conduct decontamination and medical actions that enable the quick restoration of combat power, maintain/recover essential functions that are free from the effects of chemical and biological (CB) hazards, and facilitate the return to pre-incident operational capability as soon as possible. Thrust Areas included in this Project are: (1) Biological Warfare Defense Therapeutics (2) Enabling Science (3) Reactivators of Acetylcholinesterase as Therapeutics (ReACT) (4) Emerging and Pharmaceutical-based Agent Threats (EMPATH) (5) Chemically Reactive Ocular, Wound and Dermal Therapeutics (CROWD) (6) Enhanced Survivability Coatings (7) Equipment Decontamination (8) Multifunctional Materials for Protection (MMfP) (9) Personnel Decontamination (10) Discovery of Medical countermeasures Against New and Emerging threats - Enhanced Biological Defense

| Activity (R-2A) | FY2025 | FY2026 | FY2027 |
|---|---|---|---|
| 1) Biological Warfare Defense Therapeutics | 33.4 | 20.1 | 21.7 |
| 2) Enabling Science | 10.5 | 10.5 | 2.0 |
| 3) Reactivators of Acetylcholinesterase as Therapeutics | 6.4 | 7.1 | 5.0 |
| 4) Emerging and Pharmaceutical-based Agent Threats | 0.9 | — | — |
| 5) Chemically Reactive Ocular, Wound and Dermal Therapeutics | 2.5 | — | — |
| 6) Enhanced Survivability Coatings | 0.5 | 0.6 | 0.5 |
| 7) Equipment Decontamination | 2.0 | 2.0 | 2.5 |
| 8) Multifunctional Materials for Protection | 1.9 | 2.2 | 2.3 |
| 9) Personnel Decontamination | 1.0 | 0.3 | — |
| 10) Discovery of Medical countermeasures Against New and Emerging threats - Enhanced Biological Defense | 3.2 | 2.3 | — |

> R-2A activities carry the prior, current and budget year only — no five-year plan. Coverage is partial, so count them, never total them.

### Project EN2 — Enabling Investments (Applied Research)

The Enabling Investments Applied Research Project focuses on characterization of safety/efficacy models and microphysiological models that mimic the human response to biological and chemical agents. This area also develops and provides infrastructure capabilities to conduct defensive classified Department of War (DoW) work in laboratories, the appropriate DoW workforce to execute Science & Technology (S&T) in high containment at various levels of classification, and executes a robust emerging biothreat portfolio to enable readiness for future incidents. Thrust Areas included in this Project are: (1) Biological Warfare Defense Prophylaxis - Comparing Models to Organ Tissue Equivalents (2) Enabling Science

| Activity (R-2A) | FY2025 | FY2026 | FY2027 |
|---|---|---|---|
| 1) Biological Warfare Defense Prophylaxis - Comparing Models to Organ Tissue Equivalents | 2.5 | 2.5 | 1.5 |
| 2) Enabling Science | 20.0 | 16.0 | — |

> R-2A activities carry the prior, current and budget year only — no five-year plan. Coverage is partial, so count them, never total them.

## Mission & acquisition strategy

This program element (PE) resources Applied Research across the Understand, Protect, Mitigate, and Enabling Investments portfolios. Chemical and Biological Defense Program (CBDP) investments provide an integrated, layered capability to enable Department of War (DoW) missions in a chemical and biological environment, ranging from combat operations to domestic incident prevention and response. The Projects in this PE support applied research in the areas of physical technologies, non-traditional agent (NTA) medical and physical defense technologies, and medical technologies.

## Related program elements

- [0603384BP — Chemical and Biological Defense Program - Advanced Development](https://hitchintel.com/programs/0603384BP) (Defense-Wide)
- [0604384BP — Chemical and Biological Defense Program - EMD](https://hitchintel.com/programs/0604384BP) (Defense-Wide)
- [0303248F — Air Force Command and Control (C2) Comm](https://hitchintel.com/programs/0303248F) (Air Force)
- [0305015F — Applications Development](https://hitchintel.com/programs/0305015F) (Air Force)

## Source & machine access

- **Source:** FY2027 Office of the Secretary of Defense RDT&E Budget Justification, Exhibits R-2/R-3, PE 0602384BP (PB PB2027); FY2027 NDAA committee marks (as of 2026-07-27).
- **MCP:** `mcp.hitchintel.com` — `budget_get_program_element(pe="0602384BP")`.

*HitchAI is an independent intelligence service, not affiliated with the U.S. Department of Defense. Budget figures are requests/estimates, not obligations.*