# 8) Nerve Agent Prophylaxis

**R-2A activity** of project PT2 — Protect (Applied Research)  
**Program element:** 0602384BP — Chemical and Biological Defense Program  
**Component:** Defense-Wide · **Budget Activity:** 2  
**Vintage:** President's Budget PB2027  
**Canonical URL:** https://hitchintel.com/programs/0602384BP/PT2/a7  
**Parent:** https://hitchintel.com/programs/0602384BP/PT2

## Summary

This activity requests $21.1M in FY2027, 27% of project PT2, up 548% on FY2026. The R-2A exhibit describes it across FY2025–FY2027, including what the FY2027 money is planned to buy.

## What the FY2027 request buys

**FY2027 planned work.** - Continue the identification and development of lead medicine candidates. - Additional drug candidates that utilize several different technical approaches will be pursued.

**FY2026 to FY2027 change.** Program/project funding transferred from another funding line. Funding transferred from Project MT2/Mitigate to pursue additional Nerve Agent Prophylaxes drug candidates.

## Before the request year

**FY2026 plans — current year.** - Complete vaccine efficacy studies against multiple agents. - Continue to develop one or more alternative nerve agent prophylactic technologies as a risk mitigation step

**FY2025 accomplishments.** - Continued the identification and development of lead medicine candidates. Multiple candidates were pursued. - Continued to perform studies on how well the protective medicines work (efficacy), how they move into, through and out of the body (pharmacokinetics), and if there are any significant harmful effects (toxicity).

## Funding

| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 3.8 |
| FY2026 | Enacted | 3.3 |
| FY2027 | Request | 21.1 |

> Prior, current and budget year only — an R-2A activity carries no five-year plan. It sums exactly into its project in the request year and not necessarily in any other.

## Other activities in project PT2

- [2) Biological Warfare Defense Prophylaxis - Enhanced Biological Defense](https://hitchintel.com/programs/0602384BP/PT2/a1) — FY2027 20.9
- [1) Biological Warfare Defense Prophylaxis](https://hitchintel.com/programs/0602384BP/PT2/a0) — FY2027 20.9
- 5) Multifunctional Materials for Protection — FY2027 8.5
- 6) Protective Garments — FY2027 3.3
- 4) All-Hazards and Respiratory Protection — FY2027 1.9
- 3) Air Purification Enhancements — FY2027 1.4
- 7) Enabling Science — FY2027 —

## Source & machine access

- **Source:** FY2027 Office of the Secretary of Defense RDT&E Budget Justification, Exhibit R-2A, PE 0602384BP project PT2 (PB PB2027). Narrative is the government's own text.
- **No marks, no contractors at this grain** — congressional marks land on the program element and R-3 performers on the project.
- **MCP:** `mcp.hitchintel.com` — `budget_get_activity`.

*HitchAI is an independent intelligence service, not affiliated with the U.S. Department of Defense. Budget figures are requests/estimates, not obligations.*