What the FY2027 request buys
Verbatim from the R-2A exhibit for project PT3 of PE 0603384BP. This is the budget justification's own description of work that has not happened yet — the one thing no other level of the budget carries.
- Continue the development and optimization of lead medicine candidates at standards suitable for submission to the FDA. - Additional drug candidates that utilize different technical approaches will be pursued.
Program/project funding transferred from another funding line. Funding transferred from MT3/Mitigate to pursue additional Nerve Agent Prophylaxes drug candidates.
FY2025–FY2026: what came before
Prior-year accomplishments and current-year plans from the same exhibit. Context for the FY2027 plan, not a series — an activity partitions its project exactly in the request year, but can under-cover it in earlier years.
- Continue development of protective drugs to increase the protective lifetime within the body, including improvements in manufacturing development. - Initiate Phase 1 clinical studies for one protective drug.
- Continued to perform studies on how well the protective medicines work (efficacy), how they move into, through and out of the body (pharmacokinetics), and if there are any significant harmful effects (toxicity). These continuing studies are performed at standards suitable for submission to the FDA. - Initiated efforts of one or more alternative nerve agent prophylactic technologies as a risk mitigation step. Studies performed at standards suitable for submission to the FDA.
Three years, and no five-year plan
An R-2A activity publishes the prior year, the current year and the budget year. The FYDP outyears exist at project and program-element level and are deliberately absent here rather than inferred. Estimate types are colored and never summed into one figure.
| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 12.1 |
| FY2026 | Enacted | 10.2 |
| FY2027 | Request | 24.0 |
This activity is 42% of project PT3's FY2027 request and 7.7% of PE 0603384BP's. In the request year the activities under a project sum to it exactly; in the current year they under-cover it in about 9% of cases, so an activity's delta can legitimately exceed its parent's and the two must not be compared row to row.
10 activities in project PT3
Every R-2A line of this project, largest FY2027 request first. Linked where the activity has enough of its own narrative to carry a page; the rest are shown in full on the project page.