# 2) Nerve Agent Prophylaxis

**R-2A activity** of project PT3 — Protect (ATD)  
**Program element:** 0603384BP — Chemical and Biological Defense Program - Advanced Development  
**Component:** Defense-Wide · **Budget Activity:** 3  
**Vintage:** President's Budget PB2027  
**Canonical URL:** https://hitchintel.com/programs/0603384BP/PT3/a1  
**Parent:** https://hitchintel.com/programs/0603384BP/PT3

## Summary

This activity requests $24.0M in FY2027, 42% of project PT3, up 135% on FY2026. The R-2A exhibit describes it across FY2025–FY2027, including what the FY2027 money is planned to buy.

## What the FY2027 request buys

**FY2027 planned work.** - Continue the development and optimization of lead medicine candidates at standards suitable for submission to the FDA. - Additional drug candidates that utilize different technical approaches will be pursued.

**FY2026 to FY2027 change.** Program/project funding transferred from another funding line. Funding transferred from MT3/Mitigate to pursue additional Nerve Agent Prophylaxes drug candidates.

## Before the request year

**FY2026 plans — current year.** - Continue development of protective drugs to increase the protective lifetime within the body, including improvements in manufacturing development. - Initiate Phase 1 clinical studies for one protective drug.

**FY2025 accomplishments.** - Continued to perform studies on how well the protective medicines work (efficacy), how they move into, through and out of the body (pharmacokinetics), and if there are any significant harmful effects (toxicity). These continuing studies are performed at standards suitable for submission to the FDA. - Initiated efforts of one or more alternative nerve agent prophylactic technologies as a risk mitigation step. Studies performed at standards suitable for submission to the FDA.

## Funding

| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 12.1 |
| FY2026 | Enacted | 10.2 |
| FY2027 | Request | 24.0 |

> Prior, current and budget year only — an R-2A activity carries no five-year plan. It sums exactly into its project in the request year and not necessarily in any other.

## Other activities in project PT3

- [1) Biological Warfare Defense Prophylaxis](https://hitchintel.com/programs/0603384BP/PT3/a0) — FY2027 23.6
- 7) Protective Garments — FY2027 4.1
- 4) All-Hazards and Respiratory Protection — FY2027 2.9
- 8) Air Purification Enhancements - Enhanced Biological Defense — FY2027 2.0
- 3) Air Purification Enhancements — FY2027 0.8
- 6) Multifunctional Materials for Protection — FY2027 0.2
- 5) Enhanced Survivability Coatings — FY2027 —
- 9) All-hazards and Respiratory Protection - Enhanced Biological Defense — FY2027 —
- 10) Protective Garments - Enhanced Biological Defense — FY2027 —

## Source & machine access

- **Source:** FY2027 Office of the Secretary of Defense RDT&E Budget Justification, Exhibit R-2A, PE 0603384BP project PT3 (PB PB2027). Narrative is the government's own text.
- **No marks, no contractors at this grain** — congressional marks land on the program element and R-3 performers on the project.
- **MCP:** `mcp.hitchintel.com` — `budget_get_activity`.

*HitchAI is an independent intelligence service, not affiliated with the U.S. Department of Defense. Budget figures are requests/estimates, not obligations.*