What project LF1 buys
This Project (LF1) focuses on fundamental efforts to understand living systems' responses to biological or chemical agents to support detection, protection, diagnostics, and medical treatment. Research focuses on studying factors that influence the behavior of chemicals, toxins, and pathogens in relation to the host or target. Understanding host/agent interactions can drive the exploration of novel approaches to detect, diagnose or protect against threats. Research also focuses on medical countermeasures for improved efficacy against a wide array of current and future threat agents. This project is a key enabler supporting the Understand, Protect, and Mitigate portfolios.
Project LF1 funding, FY2025–FY2031
Prior years are actuals, the budget year is the request, and the outyears are the FYDP plan. Estimate types are colored and never summed into one figure. Projects carry the full five-year plan; the activities inside them stop at the budget year.
| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 20.4 |
| FY2026 | Enacted | 17.7 |
| FY2027 | Request | 16.1 |
| FY2028 | Outyear | 14.8 |
| FY2029 | Outyear | 14.0 |
| FY2030 | Outyear | 13.8 |
| FY2031 | Outyear | 13.7 |
1 accomplishment / planned program
The R-2A exhibit — the only level of the budget that describes work that has not happened yet. Activities carry the prior, current and budget year only, no five-year plan. Each describes FY2027 work in enough detail to have its own page; the rest are shown here in full. Coverage is partial across the corpus, so count activities, never total them.
- Organoid Technology – Continue investigating cellular toxicity and metabolic profiles in organoids and evaluate relevance to safety/efficacy model data. Determine inflammatory signaling in models that are relevant to human cells. Evaluate and develop alternative models that mimic human response for rapid drug development, which can…
Read the FY2027 plan →