Project LF1
$16.1MFY2027 request ▼ 9%Life Sciences (Basic Research)
FY2025 actual$20.4M
FY2026 enacted$17.7M
FY2027 request$16.1M
FY2027 Request
$27.4M
▼ 2.9% vs FY2026
FY2026 Enacted
$28.2M
▼ 24% vs FY2025
FY2025 Actual
$37.0M
Prior year
Roll-up of 2 projects. Projects are the summable leaves — the PE total is their sum, never added to it.
For fiscal year 2027, Defense-Wide agencies are requesting $27.4M for Chemical and Biological Defense Program under RDT&E program element 0601384BP, down 2.9% from FY2026.
Funding trajectory
Funding profile, FY2025–FY2031
Prior years are actuals, the budget year is the request, and the outyears are the FYDP plan. Estimate types are colored and never summed into one figure.
Actual Enacted Request Outyear (FYDP)
| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 37.0 |
| FY2026 | Enacted | 28.2 |
| FY2027 | Request | 27.4 |
| FY2028 | Outyear | 24.9 |
| FY2029 | Outyear | 24.0 |
| FY2030 | Outyear | 23.6 |
| FY2031 | Outyear | 23.4 |
Where it sits
Acquisition lifecycle
This program is funded in RDT&E Budget Activity 1 — Basic Research.
Current
Research
BA 1–2
Later
Advanced Technology
BA 3
Later
Prototyping
BA 4
Later
Development & Fielding
BA 5–7
Inside the program element
2 projects roll up into PE 0601384BP
Projects are the summable leaves — the PE total is their sum, never added to it. Program elements and projects carry the full five-year plan; activities stop at the budget year. This PE moves -3% overall, which can hide much larger swings below.
Project PS1
$11.3MFY2027 request ▲ 7%Physical Sciences (Basic Research)
FY2025 actual$16.5M
FY2026 enacted$10.6M
FY2027 request$11.3M
Congressional action
Congressional marks
Committee marks on the FY2027 request. Adds and cuts are reconciled in conference before they become law.
RequestPresident's Budget
$27.4M
House NDAA (HASC)HASC
$27.4M full · +$0
Senate NDAA (SASC)SASC
$27.4M full · +$0
House Approps (HAC-D)HAC_D
$27.4M full · +$0
unresolved as of 2026-07-27. These are FY2027 authorization marks (NDAA); appropriations and the conference agreement may differ.
Program detail
Mission & acquisition strategy
This program element (PE) resources basic research efforts directed at promoting theoretical and experimental research in Life and Physical Sciences. These efforts are part of an integrated portfolio addressing emerging chemical and biological (CB) threats, and are a key enabler supporting the Understand, Protect, and Mitigate portfolios. Basic research focuses on pursuing fundamental science to advance a greater understanding of threats, improve situational awareness of emerging threats, and support transformative research in emerging research areas that can potentially foster paradigm shifts in the CB defense research arena to a rapid response capability.
Project LF1, PS1 — Life Sciences (Basic Research)
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Ask this program element
Answers are generated from the figures on this page — the FY2027 justification exhibits and the marks tracked above — and nothing else is consulted. Confirm any figure against the cited exhibit before you use it externally.
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Questions this page can answer
How does the FY2027 request compare with FY2026, and what does the five-year plan show?What did the FY2027 NDAA committees do to this request?Which project inside PE 0601384BP is growing fastest, and which is shrinking?In plain terms, what is this program element for and how is it being acquired?
This page carries the budget justification and the NDAA marks — nothing else. For what a contractor has actually been obligated, the ledger is at hitchintel.com/vendors; for live solicitations, hitchintel.com/opportunities. Both are member surfaces.
Provenance
Cite this page
Sources
FY2027 Office of the Secretary of Defense RDT&E Budget Justification · Exhibits R-2 / R-3 · PE 0601384BP (President's Budget PB2027) — and FY2027 NDAA committee marks, as tracked 2026-07-27.
Suggested citation
HitchAI, "Chemical and Biological Defense Program (PE 0601384BP)," federal budget intelligence, PB2027 vintage. hitchintel.com/programs/0601384BP
Machine access
Markdown twin
/programs/0601384BP.md · MCP mcp.hitchintel.com → budget_get_program_element, budget_get_cong_marksFY2027 Request
$16.1M
▼ 8.7% vs FY2026
FY2026 Enacted
$17.7M
▼ 14% vs FY2025
FY2025 Actual
$20.4M
Prior year
Life Sciences (Basic Research) — one RDT&E project inside PE 0601384BP. Congressional marks are recorded on the program element, not on a project.
Project LF1 — Life Sciences (Basic Research) — requests $16.1M in FY2027, 59% of the $27.4M requested for program element 0601384BP. Year over year it falls 8.7% against FY2026.
Funding trajectory
Project LF1 funding, FY2025–FY2031
Prior years are actuals, the budget year is the request, and the outyears are the FYDP plan. Estimate types are colored and never summed into one figure. Projects carry the full five-year plan; the activities inside them stop at the budget year.
Actual Enacted Request Outyear (FYDP)
| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 20.4 |
| FY2026 | Enacted | 17.7 |
| FY2027 | Request | 16.1 |
| FY2028 | Outyear | 14.8 |
| FY2029 | Outyear | 14.0 |
| FY2030 | Outyear | 13.8 |
| FY2031 | Outyear | 13.7 |
Inside the project
1 accomplishment / planned program
The R-2A exhibit. Activities carry the prior, current and budget year only — no five-year plan — and they are descriptive: coverage is partial and they do not always add back to the project, so count them, never total them. Opening lines only here — the full year-by-year narrative is on the project page.
1) Life Sciences▼ 9%
FY2025 actual$20.4M
FY2026 enacted$17.7M
FY2027 request$16.1M
- Organoid Technology – Continue investigating cellular toxicity and metabolic profiles in organoids and evaluate relevance to safety/efficacy model data. Determine inflammatory signaling in models that are relevant to human cells. Evaluate and develop alternative models that mimic human response for rapid drug development, which can…
Read the FY2027 plan →Project detail
What project LF1 buys
This Project (LF1) focuses on fundamental efforts to understand living systems' responses to biological or chemical agents to support detection, protection, diagnostics, and medical treatment. Research focuses on studying factors that influence the behavior of chemicals, toxins, and pathogens in relation to the host or target. Understanding host/agent interactions can drive the exploration of novel approaches to detect, diagnose or protect against threats. Research also focuses on medical countermeasures for improved efficacy against a wide array of current and future threat agents. This project is a key enabler supporting the Understand, Protect, and Mitigate portfolios.
FY2027 Request
$11.3M
▲ 6.9% vs FY2026
FY2026 Enacted
$10.6M
▼ 36% vs FY2025
FY2025 Actual
$16.5M
Prior year
Physical Sciences (Basic Research) — one RDT&E project inside PE 0601384BP. Congressional marks are recorded on the program element, not on a project.
Project PS1 — Physical Sciences (Basic Research) — requests $11.3M in FY2027, 41% of the $27.4M requested for program element 0601384BP. Year over year it grows 6.9% against FY2026.
Funding trajectory
Project PS1 funding, FY2025–FY2031
Prior years are actuals, the budget year is the request, and the outyears are the FYDP plan. Estimate types are colored and never summed into one figure. Projects carry the full five-year plan; the activities inside them stop at the budget year.
Actual Enacted Request Outyear (FYDP)
| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 16.5 |
| FY2026 | Enacted | 10.6 |
| FY2027 | Request | 11.3 |
| FY2028 | Outyear | 10.1 |
| FY2029 | Outyear | 10.0 |
| FY2030 | Outyear | 9.8 |
| FY2031 | Outyear | 9.8 |
Inside the project
1 accomplishment / planned program
The R-2A exhibit. Activities carry the prior, current and budget year only — no five-year plan — and they are descriptive: coverage is partial and they do not always add back to the project, so count them, never total them. Opening lines only here — the full year-by-year narrative is on the project page.
FY2025 actual$16.5M
FY2026 enacted$10.6M
FY2027 request$11.3M
- Continue to identify and characterize innovative materials for next generation protection and detection proof-of-concept for chemical and biological defense. - Continue to employ artificial intelligence and machine learning approaches for material discovery and design parameters to synthesize new materials that destroy chemical and…
Read the FY2027 plan →Project detail
What project PS1 buys
This Project (PS1) advances fundamental scientific knowledge in physical science areas that include chemistry, physics, materials science, environmental science, and nanotechnology that could potentially lead to transformational chemical and biological (CB) defensive capabilities enhancing warfighter performance and safety. This project is a key enabler supporting the Understand, Protect, and Mitigate portfolios.