What project EMR-04 buys
The Basic Operational Medical Science project will explore and develop basic research in medical-related information and technology leading to fundamental discoveries, tools, and applications critical to overcoming DoW challenges. This project will address the Department's identified warfighter medical care needs related to prevention and treatment of infectious disease, real-time healthcare interventions of acute and chronic illness and injury, and interventions for improved warfighter resilience and performance against operational stressors. Prior to FY 2026, efforts in this PE were funded in PE 0601117E, Project MED-01.
Project EMR-04 funding, FY2025–FY2031
Prior years are actuals, the budget year is the request, and the outyears are the FYDP plan. Estimate types are colored and never summed into one figure. Projects carry the full five-year plan; the activities inside them stop at the budget year.
| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2025 | Actual | 0.0 |
| FY2026 | Enacted | 77.9 |
| FY2027 | Request | 96.6 |
| FY2028 | Outyear | 131.0 |
| FY2029 | Outyear | 133.1 |
| FY2030 | Outyear | 138.5 |
| FY2031 | Outyear | 140.5 |
9 accomplishments / planned programs
The R-2A exhibit — the only level of the budget that describes work that has not happened yet. Activities carry the prior, current and budget year only, no five-year plan. 4 of them describe FY2027 work in enough detail to have their own page; the rest are shown here in full. Coverage is partial across the corpus, so count activities, never total them.
- Initiate exploration of approaches to improve assessments and diagnostics for predictive and preventative purposes. - Identify assessment paradigm for biological and artificial intelligence problem solving separately and in tandem. - Investigate high-throughput characterization technologies to examine molecular interactions and…
Read the FY2027 plan →- Generalize computational models by incorporating available data from public protein databases. - Incorporate machine learning methods with physics-based models to provide speed and accuracy of function prediction. - Evaluate the optimized model performance in capability demonstrations to predict molecular function from folding, binding…
Read the FY2027 plan →- Integrate and miniaturize neuromodulation and sensing technologies within a single ingestible form factor for closed-loop control. - Further develop, test, and finalize biomarker sensing for identified biomarker(s). - Finalize integration of stimulation modalities (electrical and/or mechanical) to modulate the systemic stress response.
Read the FY2027 plan →- Begin to define neural circuits involved in safe anesthesia effects. - Demonstrate novel actionable molecular targets that contribute to the effects of anesthesia. - Complete computational screens and select hit drug candidates against novel molecular targets. - Initiate novel drug design for molecular targets of anesthesia.
Read the FY2027 plan →FY2027 planned work - Demonstrate that developed countermeasures prevent pathogen growth and increase host survival in single fungal and bacterial pathogen exposures in blood following burn trauma. - Demonstrate that countermeasures are non-toxic and do not produce a response from the immune system in the host following burn trauma. - Validate the countermeasures' ability to prevent pathogen growth and increase host survival in single fungal and single bacterial pathogen exposures following burn trauma. - Refine development of countermeasures that prevent pathogen growth and increase host survival in mixed-pathogen (fungal and bacterial) exposures in blood following blast trauma.
FY2026 to FY2027 change The FY 2027 increase reflects minor program repricing.
FY2026 plans — current year - Produce countermeasures at scale to support animal model testing. - Complete validation of countermeasures' ability to prevent pathogen growth and increase host survival in single fungal and single bacterial pathogen exposures. - Refine development of countermeasures that prevent pathogen growth and increase host survival in single fungal and bacterial pathogen exposures in blood following burn trauma. - Refine development of countermeasures that are non-toxic and non-immunogenic to the host following burn trauma.
FY2026 to FY2027 change The FY 2027 decrease reflects program completion.
FY2026 plans — current year - Begin pressure tests to experimentally validate simulations for tailored DoW use cases. - Investigate and evaluate new approaches and combinations thereof to develop simulations of fundamental biological processes and responses to stimuli or stress. - Begin validating simulations of fundamental biological processes and responses to stimuli or stress. - Develop approaches to evaluate computational parameter space to optimize simulations of fundamental biological processes.
FY2026 to FY2027 change The FY 2027 decrease reflects program completion.
FY2026 plans — current year - Complete data collection of biobehavioral signatures of warfighter and team performance. - Validate bio-behavioral signatures using predictive models of team performance. - Conduct Critical Task Analysis for two additional teaming-related use cases and develop custom metrics for each use case. - Create testbeds for two additional teaming-related use cases to explore generalizability of bio-behavioral signatures and predictive models.
FY2026 to FY2027 change The FY 2027 decrease reflects program completion.
FY2026 plans — current year - Demonstrate medical countermeasures against pathogenic bacteria and/or their toxins with greater efficacy than state-of-the-art antibiotic therapies.
FY2026 to FY2027 change The FY 2027 decrease reflects program completion.
FY2026 plans — current year - Identify molecules in the blood that correspond to sleep loss and its effects on cognitive function. - Identify potential intervention targets for mitigating deleterious effects of sleep loss.