What the FY2027 request buys
Verbatim from the R-2A exhibit for project EMR-04 of PE 0601122E. This is the budget justification's own description of work that has not happened yet — the one thing no other level of the budget carries.
- Generalize computational models by incorporating available data from public protein databases. - Incorporate machine learning methods with physics-based models to provide speed and accuracy of function prediction. - Evaluate the optimized model performance in capability demonstrations to predict molecular function from folding, binding and cooperativity. - Validate the developed computational models on select datasets to assess overall model performance in drug-resistance, antibody and enzyme design.
The FY 2027 increase reflects testing and evaluation efforts to integrate program models and perform additional capability demonstrations.
FY2026: the year under way
Prior-year accomplishments and current-year plans from the same exhibit. Context for the FY2027 plan, not a series — an activity partitions its project exactly in the request year, but can under-cover it in earlier years.
- Design rapid computational models on a small subset of protein families to incorporate the dynamics and function of proteins. - Evaluate models for the correlation of dynamics and function of known protein sequences to assess model extensibility. - Evaluate computational model performance in a capability demonstration to predict the unknown molecular function of novel sequences.
Three years, and no five-year plan
An R-2A activity publishes the prior year, the current year and the budget year. The FYDP outyears exist at project and program-element level and are deliberately absent here rather than inferred. Estimate types are colored and never summed into one figure.
| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2026 | Enacted | 11.5 |
| FY2027 | Request | 14.4 |
This activity is 15% of project EMR-04's FY2027 request and 3.7% of PE 0601122E's. In the request year the activities under a project sum to it exactly; in the current year they under-cover it in about 9% of cases, so an activity's delta can legitimately exceed its parent's and the two must not be compared row to row.
9 activities in project EMR-04
Every R-2A line of this project, largest FY2027 request first. Linked where the activity has enough of its own narrative to carry a page; the rest are shown in full on the project page.