What the FY2027 request buys
Verbatim from the R-2A exhibit for project EMR-04 of PE 0601122E. This is the budget justification's own description of work that has not happened yet — the one thing no other level of the budget carries.
- Begin to define neural circuits involved in safe anesthesia effects. - Demonstrate novel actionable molecular targets that contribute to the effects of anesthesia. - Complete computational screens and select hit drug candidates against novel molecular targets. - Initiate novel drug design for molecular targets of anesthesia.
The FY 2027 decrease reflects minor program repricing.
FY2026: the year under way
Prior-year accomplishments and current-year plans from the same exhibit. Context for the FY2027 plan, not a series — an activity partitions its project exactly in the request year, but can under-cover it in earlier years.
- Identify novel molecular targets of anesthesia. - Conduct computational modeling to test efficacy of small molecules binding to established protein targets. - Define neural circuitry mechanisms that underlie anesthetic actions in an animal model. - Experimentally validate anesthesia associated pathways and molecular targets identified in screening approaches. - Validate and demonstrate predictive capabilities of physiological computational model of anesthetic drugs in single/poly-trauma physiologies.
Three years, and no five-year plan
An R-2A activity publishes the prior year, the current year and the budget year. The FYDP outyears exist at project and program-element level and are deliberately absent here rather than inferred. Estimate types are colored and never summed into one figure.
| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2026 | Enacted | 10.5 |
| FY2027 | Request | 10.3 |
This activity is 11% of project EMR-04's FY2027 request and 2.7% of PE 0601122E's. In the request year the activities under a project sum to it exactly; in the current year they under-cover it in about 9% of cases, so an activity's delta can legitimately exceed its parent's and the two must not be compared row to row.
9 activities in project EMR-04
Every R-2A line of this project, largest FY2027 request first. Linked where the activity has enough of its own narrative to carry a page; the rest are shown in full on the project page.