R-2A Activity · President's Budget PB2027

BioFuse

FY2027 Request
$33.6M
▲ 438% vs FY2026
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This activity requests $33.6M in FY2027, 23% of project WP-01, up 438% on FY2026. The R-2A exhibit describes it across FY2026–FY2027, including what the FY2027 money is planned to buy.

FY2027 Request
$33.6M
▲ 438% vs FY2026
FY2026 Enacted
$6.3M
In law
Planned work

What the FY2027 request buys

Verbatim from the R-2A exhibit for project WP-01 of PE 0602024E. This is the budget justification's own description of work that has not happened yet — the one thing no other level of the budget carries.

FY2027 planned work

- Demonstrate model-driven, rational design of biological candidates and increase strength and selectivity of metal/mineral interactions. - Evaluate top biological metal/mineral processing candidates under real-world processing workflows and conditions. - Perform process durability assessments. - Refine the list of candidate biological targets. - Produce a high purity metal/mineral product from a real-world feedstock. - Produce a high purity metal/mineral product from a traditionally uneconomical waste feedstock. - Demonstrate potential for technological scale-up using real world feedstocks. - Initiate a techno-economic analysis to validate the commercial viability and industrial potential of the technology. - Assess the potential for adapting the developed bioprocessing platforms to process other metals and minerals of strategic importance to national security.

FY2026 to FY2027 change

The FY 2027 increase reflects a shift from proof-of-concept demonstrations and model development to engineering biologics for industrial processing of real-world feedstocks at scale.

Before the request year

FY2026: the year under way

Prior-year accomplishments and current-year plans from the same exhibit. Context for the FY2027 plan, not a series — an activity partitions its project exactly in the request year, but can under-cover it in earlier years.

FY2026 plans — current year

- Identify candidate biological targets that demonstrate highly selective metal interactions or properties that may be engineered to induce highly selective metal interactions. - Baseline the ability of biological candidates to successfully produce a metal or mineral product from simulated feedstocks. - Explore model-driven workflows for rapid design-build-test cycles of biological candidates.

Money

Three years, and no five-year plan

An R-2A activity publishes the prior year, the current year and the budget year. The FYDP outyears exist at project and program-element level and are deliberately absent here rather than inferred. Estimate types are colored and never summed into one figure.

2506.3FY26ENACTED33.6FY27REQUEST
Enacted Request
Fiscal YearEstimate TypeAmount ($M)
FY2026Enacted6.3
FY2027Request33.6

This activity is 23% of project WP-01's FY2027 request and 9.2% of PE 0602024E's. In the request year the activities under a project sum to it exactly; in the current year they under-cover it in about 9% of cases, so an activity's delta can legitimately exceed its parent's and the two must not be compared row to row.

Where this sits

12 activities in project WP-01

Every R-2A line of this project, largest FY2027 request first. Linked where the activity has enough of its own narrative to carry a page; the rest are shown in full on the project page.

BioFuse — this activity$33.6M ▲ 438%
Biologically Based Materials and Devices Studies and Concepts$30.1M NEWGenetic Utilization for Advanced Regulation and Defense of Indigenous And Native Species (GUARDIAN)$25.3M ▲ 181%Fleetwood$20.0M NEWeX Virentia (eXVi)$12.8M ▲ 3%Turning Upcycled Waste into Novel, Sustainable Materials$11.7M ▼ 23%
Biological Undersea Energy$5.4M ▼ 60%
Biotechnology for Challenging Environments$5.0M ▼ 19%
Field Forward Biothreat Storage Solutions for Force Protection$2.5M ▼ 78%
Strengthening Resilient Emotions and Nimble Cognition Through Engineering Neuroplasticity (STRENGTHEN)$0.6M ▼ 93%
Materiel Protection through Biologics▼ 100%
Environmental Microbes as a Bioengineering Resource (EMBER)▼ 100%
Source
FY2027 Office of the Secretary of Defense RDT&E Budget Justification · Exhibit R-2A · PE 0602024E, project WP-01 (President's Budget PB2027). Congressional marks are recorded on the program element, never on an activity.
Machine access
Markdown twin /programs/0602024E/WP-01/a7.md · MCP mcp.hitchintel.combudget_get_activity