What the FY2027 request buys
Verbatim from the R-2A exhibit for project WP-02 of PE 0602024E. This is the budget justification's own description of work that has not happened yet — the one thing no other level of the budget carries.
- Continue studies on editing cells to produce, position, and retain novel proteins in mature RBCs. - Continue computer simulation of gene editing impact on RBC metabolism and virtually optimize protein position/retention on mature RBCs. - Initiate experiments to produce, position, and retain novel proteins in mature RBCs. - Identify any changes in RBC function due to the genetic modifications when compared to unmodified cells. - Initiate simulation experiments to optimize protein position/retention on a mature RBC. - Assess the type and character of circuits possible in RBCs based on gene editing experiments and protein expression.
The FY 2027 increase reflects the expansion of studies on editing cells to produce, position, and retain novel proteins within and on the surface of RBCs.
FY2026: the year under way
Prior-year accomplishments and current-year plans from the same exhibit. Context for the FY2027 plan, not a series — an activity partitions its project exactly in the request year, but can under-cover it in earlier years.
- Initiate studies on editing cells to produce, position, and retain novel proteins in mature red blood cells (RBCs). - Run a computer simulation of the gene editing impact on RBC metabolism.
Three years, and no five-year plan
An R-2A activity publishes the prior year, the current year and the budget year. The FYDP outyears exist at project and program-element level and are deliberately absent here rather than inferred. Estimate types are colored and never summed into one figure.
| Fiscal Year | Estimate Type | Amount ($M) |
|---|---|---|
| FY2026 | Enacted | 4.0 |
| FY2027 | Request | 21.2 |
This activity is 11% of project WP-02's FY2027 request and 5.8% of PE 0602024E's. In the request year the activities under a project sum to it exactly; in the current year they under-cover it in about 9% of cases, so an activity's delta can legitimately exceed its parent's and the two must not be compared row to row.
14 activities in project WP-02
Every R-2A line of this project, largest FY2027 request first. Linked where the activity has enough of its own narrative to carry a page; the rest are shown in full on the project page.